SNX29抗体;SNX29 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12227(SNX29 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P12227(SNX29 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SNX29 antibody is a tool used to detect sorting nexin 29 (SNX29), a protein belonging to the sorting nexin (SNX) family, which regulates membrane trafficking and protein sorting in eukaryotic cells. SNX29 contains a Phox homology (PX) domain, a characteristic feature of SNX proteins that binds phosphoinositides to facilitate membrane association. While its exact biological role remains less characterized compared to other SNXs (e.g., SNX1 or SNX3), studies suggest SNX29 may participate in endosomal sorting, vesicle formation, or signaling pathways. It is hypothesized to interact with components of the retromer complex or other trafficking regulators, though mechanistic details are still under investigation.

Antibodies targeting SNX29 are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable researchers to study SNX29's expression, localization (e.g., in early endosomes, Golgi, or plasma membrane), and interactions via techniques such as Western blotting, immunofluorescence, or immunoprecipitation. Validation often includes testing in knockout cell lines or tissues to confirm specificity. SNX29 has been implicated in cellular processes like receptor recycling, cytoskeletal organization, and potentially in diseases such as cancer or neurological disorders, though direct evidence remains limited. Commercial SNX29 antibodies are available from suppliers like Abcam, Sigma-Aldrich, or Cell Signaling Technology, supporting ongoing research to elucidate its physiological and pathological roles.