SNX5抗体;SNX5 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, Jurkat cells, Primary antibody: P12226(SNX5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12226(SNX5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SNX5 antibody is a research tool designed to detect and study sorting nexin 5 (SNX5), a member of the sorting nexin family involved in membrane trafficking and intracellular protein sorting. SNX5 contains a phox homology (PX) domain, which binds to phosphatidylinositol lipids, enabling its recruitment to endosomal membranes. It plays a role in endosomal sorting, vesicle formation, and maintaining organelle dynamics, often interacting with other SNX proteins (e.g., SNX1. SNX6) to form retromer-associated complexes that regulate cargo retrieval from endosomes to the trans-Golgi network. SNX5 is implicated in diverse cellular processes, including receptor recycling, autophagy, and cellular signaling.

Antibodies targeting SNX5 are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and molecular interactions. These reagents help elucidate SNX5's role in physiological contexts (e.g., nutrient uptake, immune response) and pathological conditions, such as cancer and neurodegenerative diseases, where endosomal trafficking defects are observed. Commercial SNX5 antibodies are typically raised in rabbits or mice, with validation across species (human, mouse, rat) and applications. Researchers rely on these antibodies to explore SNX5's contribution to cellular homeostasis and disease mechanisms, making them critical for advancing studies in cell biology and therapeutic target discovery.