SNX1抗体;SNX1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: MCF7 cell lysate, Primary antibody: P12223(SNX1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12223(SNX1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

SNX1 (Sorting Nexin 1) is a member of the sorting nexin family, a group of proteins involved in membrane trafficking, endosomal sorting, and cellular signaling. These proteins typically contain a phox homology (PX) domain that facilitates binding to phosphoinositides, enabling their association with lipid membranes. SNX1 plays a critical role in endosomal sorting, particularly in the retromer-mediated retrieval of cargo proteins (e.g., cation-independent mannose 6-phosphate receptor) from endosomes to the trans-Golgi network. It also participates in regulating endosome-to-plasma membrane trafficking and autophagy processes. Dysregulation of SNX1 has been linked to neurodegenerative diseases, cancer, and metabolic disorders, highlighting its importance in cellular homeostasis.

SNX1 antibodies are essential tools for studying these functions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect SNX1 expression, localization, and interactions in various biological contexts. Researchers employ these antibodies to investigate SNX1's role in receptor recycling, endosomal dynamics, and disease mechanisms. Many commercial SNX1 antibodies are raised against specific epitopes, often within the PX or coiled-coil domains, and their specificity is validated across human, mouse, and rat models. Studies utilizing SNX1 antibodies have advanced understanding of intracellular trafficking pathways and their implications in health and disease.