SMC6抗体;SMC6 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Jurkat cells, 231 cells, hela cells, 293T cells, Primary antibody: P12218(SMC6 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12218(SMC6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12218(SMC6 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SMC6 antibody targets the Structural Maintenance of Chromosomes 6 (SMC6) protein, a key component of the SMC5/6 complex involved in maintaining genomic stability. SMC6. along with SMC5. forms a heterodimer critical for DNA repair, chromosome segregation, and replication fork stability. This complex facilitates homologous recombination repair (HRR) of DNA double-strand breaks and resolves replication-associated topological stress, ensuring faithful chromosome transmission during cell division. Dysregulation of SMC6 is linked to chromosomal aberrations, replication errors, and diseases like cancer.

SMC6 antibodies are widely used in research to study DNA damage response mechanisms, replication stress, and mitotic regulation. They enable detection of SMC6 expression, localization, and interaction partners via techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation. Studies using these antibodies have revealed SMC6's role in safeguarding replication forks in BRCA-deficient cancers and its potential as a therapeutic target. Commercial SMC6 antibodies are typically validated in model systems (e.g., human, mouse) to ensure specificity, with applications spanning basic chromatin biology to translational cancer research. Ongoing studies explore its interplay with cohesin and condensin complexes in 3D genome organization.