PROX1抗体;PROX1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: P12077(PROX1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

PROX1 (Prospero-related homeobox 1) antibody is a research tool targeting the PROX1 protein, a transcription factor critical in embryonic development and tissue differentiation. Discovered through its homology to the Drosophila Prospero gene, PROX1 regulates cell fate decisions in processes such as lymphatic vasculature formation, neurogenesis, and hepatocyte maturation. It is widely studied in developmental biology, oncology, and stem cell research due to its dual role as both a tumor suppressor and oncogene, depending on context. For example, PROX1 loss is linked to colorectal and liver cancers, while its overexpression drives glioma progression.

In research, PROX1 antibodies are utilized in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to map PROX1 expression patterns in tissues or track its subcellular localization. These studies have revealed its involvement in metabolic regulation, adult neurogenesis, and interactions with pathways like Wnt/β-catenin and Notch. Commercially available PROX1 antibodies are typically validated in specific applications and species (e.g., human, mouse), with common clonality being monoclonal or polyclonal. Researchers prioritize antibodies with high specificity, as PROX1 shares functional domains with other homeobox proteins. Its emerging role as a diagnostic biomarker in cancers and lymphatic disorders further underscores the antibody's translational relevance.