POMT1抗体;POMT1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: P12070(POMT1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12070(POMT1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12070(POMT1 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The POMT1 antibody is a crucial tool for studying the protein O-mannosyltransferase 1 (POMT1), an enzyme encoded by the *POMT1* gene. This enzyme plays a vital role in the O-mannosylation of α-dystroglycan, a post-translational modification essential for maintaining muscle membrane integrity and neuronal development. Mutations in *POMT1* are linked to severe congenital muscular dystrophies, such as Walker-Warburg syndrome and muscle-eye-brain disease, characterized by defective glycosylation of α-dystroglycan.

POMT1 antibodies are widely used in research to detect and quantify POMT1 protein expression in tissues or cultured cells, aiding in the study of its enzymatic function, interaction with POMT2 (its catalytic partner), and dysregulation in disease models. These antibodies are typically developed in host species like rabbits or mice, targeting specific epitopes of human or murine POMT1. Applications include Western blotting, immunohistochemistry, and immunofluorescence to assess protein localization and expression patterns.

In diagnostics, POMT1 antibodies help identify protein deficiencies in patient samples, supporting genetic counseling and therapeutic development. Their specificity and reliability are validated through knockdown/knockout controls. Commercially available from suppliers like Sigma-Aldrich and Abcam, these antibodies remain pivotal in advancing our understanding of glycosylation disorders and neuromuscular pathologies.