PLXNA2抗体;PLXNA2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12061(PLXNA2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12061(PLXNA2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The PLXNA2 antibody targets plexin A2 (PLXNA2), a transmembrane receptor belonging to the plexin family, which plays critical roles in neural development, immune regulation, and cellular signaling. PLXNA2 primarily functions as a receptor for semaphorin ligands, mediating axon guidance, cell migration, and angiogenesis. It is widely expressed in the nervous system and other tissues, contributing to processes like neuronal circuit formation and tissue morphogenesis. Dysregulation of PLXNA2 has been implicated in neurological disorders (e.g., autism, schizophrenia), cancer progression, and cardiovascular diseases, highlighting its therapeutic and diagnostic relevance.

PLXNA2 antibodies are essential tools for detecting the protein’s expression, localization, and interaction partners in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to study PLXNA2’s role in disease mechanisms, particularly its involvement in tumor invasiveness, metastasis, and neurodevelopmental anomalies. Structural studies reveal that PLXNA2 contains conserved semaphorin-binding and cytoplasmic GTPase-activating domains, which are critical for signal transduction. Antibodies targeting specific epitopes help dissect these functional domains or assess post-translational modifications.

Overall, PLXNA2 antibodies are vital for advancing research into neural connectivity, cancer biology, and regenerative medicine, offering insights into potential biomarkers or therapeutic targets for related pathologies.