PLCB3抗体;PLCB3 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: PC3 cells, A431 cells, mouse lung tissue, Hela cells, Primary antibody: P12057(PLCB3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12057(PLCB3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12057(PLCB3 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The phospholipase C beta 3 (PLCB3) antibody is a tool used to detect and study the PLCB3 enzyme, a member of the phospholipase C (PLC) family. PLC enzymes play critical roles in intracellular signaling by hydrolyzing phosphatidylinositol 4.5-bisphosphate (PIP2) into secondary messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG), which regulate processes like calcium release and protein kinase C activation. PLCB3. encoded by the PLCB3 gene, is specifically involved in G protein-coupled receptor (GPCR) signaling pathways and is expressed in various tissues, including the brain, immune cells, and platelets.

PLCB3 antibodies are commonly utilized in research to investigate the enzyme's expression, localization, and function in both physiological and pathological contexts. For example, studies have linked PLCB3 dysregulation to immune disorders, neurological conditions, and cancer progression. These antibodies enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize PLCB3 protein levels in cellular or tissue samples.

Most PLCB3 antibodies are produced in hosts like rabbits or mice, targeting specific epitopes of the protein. Validation methods, including knockout controls or siRNA knockdown, ensure specificity. Commercial availability from biotech vendors facilitates their use in academic and clinical research, contributing to a deeper understanding of PLCB3's role in cellular signaling and disease mechanisms. Ongoing research continues to explore its potential as a therapeutic target or diagnostic marker.