PPARGC1A抗体;PPARGC1A Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12045(PPARGC1A Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PPARGC1A (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha) antibody is a critical tool for studying the regulation of mitochondrial biogenesis, cellular energy metabolism, and adaptive thermogenesis. PPARGC1A, also known as PGC-1α, is a transcriptional coactivator that interacts with nuclear receptors and transcription factors to modulate the expression of genes involved in oxidative phosphorylation, gluconeogenesis, and fatty acid oxidation. It plays a central role in metabolic adaptation to environmental stressors, such as exercise, cold exposure, and caloric restriction. Dysregulation of PPARGC1A is linked to metabolic disorders (e.g., diabetes, obesity), neurodegenerative diseases, and aging.

Antibodies targeting PPARGC1A enable researchers to detect and quantify its expression in tissues like skeletal muscle, liver, and brown adipose tissue using techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are essential for investigating PPARGC1A’s tissue-specific functions, post-translational modifications, and interactions with partners like PPARs, ERRα, and NRF1. However, variability in antibody specificity, epitope recognition, and cross-reactivity with related isoforms (e.g., PGC-1β) can affect experimental reproducibility. Validated antibodies with clear performance data are crucial for accurate interpretation.

Overall, PPARGC1A antibodies remain indispensable in metabolic research, offering insights into molecular pathways underlying energy homeostasis and disease mechanisms. Their application continues to advance therapeutic strategies targeting mitochondrial dysfunction and metabolic syndromes.