PCDHB15抗体;PCDHB15 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12031(PCDHB15 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12031(PCDHB15 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The PCDHB15 antibody targets Protocadherin Beta 15 (PCDHB15), a member of the protocadherin β gene cluster within the cadherin superfamily. Protocadherins are transmembrane proteins critical for cell-cell adhesion, neuronal connectivity, and synaptic specificity in the central nervous system. The β-cluster consists of 16 genes (PCDHB1-PCDHB16) that encode diverse cell-surface proteins, with PCDHB15 playing potential roles in neural circuit formation, axon guidance, and synaptic plasticity. Its extracellular cadherin repeats mediate calcium-dependent homophilic interactions, while its cytoplasmic domain may interact with intracellular signaling molecules.

Antibodies against PCDHB15 are primarily used in neuroscience research to study its expression patterns, subcellular localization, and functional roles in brain development and disorders. They enable detection via techniques like immunohistochemistry, Western blotting, and immunofluorescence. Emerging studies suggest PCDHB15 may contribute to neurodevelopmental conditions, though its specific mechanisms remain under investigation. Some research links protocadherin dysregulation to autism spectrum disorders and schizophrenia, positioning PCDHB15 as a protein of interest in these contexts. Commercial antibodies are typically validated for specificity against recombinant proteins or knockout controls, though cross-reactivity with other β-protocadherins remains a consideration due to sequence homology. Ongoing studies aim to clarify its tissue distribution beyond the nervous system and potential roles in cancer progression.