PCDHAC1抗体;PCDHAC1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: P12028(PCDHAC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P12028(PCDHAC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12028(PCDHAC1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The PCDHAC1 antibody is a research tool designed to detect protocadherin alpha cluster 1 (PCDHAC1), a member of the protocadherin alpha subfamily within the cadherin superfamily. Protocadherins are transmembrane proteins critical for cell-cell adhesion, neuronal development, and synaptic specificity in the central nervous system. The PCDHAC1 gene, located in the α-protocadherin cluster on human chromosome 5. encodes a calcium-dependent adhesion protein with six extracellular cadherin repeats, a transmembrane domain, and a variable cytoplasmic tail. These proteins are thought to contribute to neural circuit formation by promoting self-avoidance and neuronal diversity through stochastic gene expression.

The PCDHAC1 antibody is commonly used in neuroscience and developmental biology to study its expression pattern, localization, and function in neural tissues. Applications include immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) in models ranging from human tissues to rodents. Dysregulation of PCDHAC1 has been implicated in neurodevelopmental disorders and certain cancers, making this antibody valuable for exploring disease mechanisms. Commercial PCDHAC1 antibodies are typically raised against specific epitopes, such as recombinant protein fragments, and require validation for specificity via knockout controls or siRNA knockdown. Researchers emphasize its role in understanding synaptic plasticity, axon guidance, and potential diagnostic or therapeutic targets.