NLRP10抗体;NLRP10 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11985(NLRP10 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11985(NLRP10 Antibody) at dilution 1/45. (Original magnification: ×200)    

  
  

NLRP10 (NOD-like receptor family pyrin domain-containing 10) is a member of the NLR family of intracellular pattern recognition receptors (PRRs), which play critical roles in innate immunity and inflammation. Unlike other NLRP proteins, NLRP10 lacks the leucine-rich repeat (LRR) domain typically involved in ligand sensing, suggesting distinct regulatory mechanisms. It is expressed in various tissues, including the skin, gastrointestinal tract, and immune cells, and has been implicated in both antimicrobial defense and immune homeostasis. Studies highlight its role in regulating inflammasome-independent pathways, dendritic cell migration, and T-cell responses. Dysregulation of NLRP10 is associated with inflammatory diseases, such as atopic dermatitis, psoriasis, and inflammatory bowel disease.

NLRP10 antibodies are essential tools for investigating its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry. Research using these antibodies has revealed NLRP10's interactions with signaling adaptors (e.g., ASC) and caspases, as well as its involvement in NF-κB and MAPK pathways. However, its exact mechanisms remain debated, partly due to conflicting data from different antibody clones or experimental models. Recent efforts focus on developing highly specific monoclonal antibodies to clarify NLRP10's role in disease pathogenesis and its potential as a therapeutic target.