NCKAP1抗体;NCKAP1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11968(NCKAP1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of NCKAP1 Antibody**

NCKAP1 (NCK-associated protein 1), also known as Hem-1. is a scaffolding protein involved in regulating cytoskeletal reorganization and cell migration, particularly in immune cells. It is a key component of the WAVE regulatory complex (WRC), which activates the Arp2/3 complex to drive actin polymerization—a critical process for cellular motility, adhesion, and immune synapse formation. NCKAP1 interacts with signaling molecules like NCK and WAVE2. linking receptor activation to cytoskeletal dynamics.

Studies highlight its role in immune function, including neutrophil chemotaxis, T-cell activation, and B-cell trafficking. Dysregulation of NCKAP1 is associated with immunodeficiencies, neurological disorders, and cancers. For example, loss-of-function mutations may impair immune cell migration, while overexpression has been observed in certain leukemias and lymphomas.

NCKAP1 antibodies are vital tools for investigating its expression, localization, and interactions in disease models. They enable techniques like Western blotting, immunoprecipitation, and immunofluorescence, aiding research on mechanisms underlying cancer metastasis, immune dysregulation, and developmental defects. These antibodies also help explore NCKAP1’s potential as a biomarker or therapeutic target in pathologies linked to cytoskeletal or signaling abnormalities.