MT-ND6抗体;MT-ND6 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11959(MT-ND6 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11959(MT-ND6 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The MT-ND6 antibody is a tool used to detect the mitochondrial NADH dehydrogenase 6 (MT-ND6) protein, a subunit of Complex I in the mitochondrial electron transport chain (ETC). MT-ND6 is encoded by the mitochondrial DNA (mtDNA) and plays a critical role in oxidative phosphorylation (OXPHOS), contributing to ATP production. Mutations in the MT-ND6 gene are linked to mitochondrial disorders, such as Leber’s hereditary optic neuropathy (LHON), Leigh syndrome, and certain cancers, making the antibody valuable for studying these pathologies.

Researchers use MT-ND6 antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and dysfunction in mitochondrial diseases or metabolic studies. The antibody helps identify reduced Complex I activity, altered mitochondrial morphology, or mtDNA mutations affecting energy metabolism. It is also employed in cancer research, as altered MT-ND6 expression may influence tumor progression via metabolic reprogramming. Commercial MT-ND6 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human protein. Validation includes testing in knockdown models or tissues with known MT-ND6 deficiencies to ensure specificity. Proper controls are essential due to potential cross-reactivity with other mitochondrial proteins or isoforms. Overall, this antibody serves as a key reagent in exploring mitochondrial biology and disease mechanisms.