MAP3K11抗体;MAP3K11 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: MCF7, PC3, LO2, NIH/3T3 cell lysates, Primary antibody: P11949(MAP3K11 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 10 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P11949(MAP3K11 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11949(MAP3K11 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The MAP3K11 antibody is a crucial tool for studying the mitogen-activated protein kinase kinase kinase 11 (MAP3K11), also known as MLK3 or PTK1. This serine/threonine kinase belongs to the MAP3K family and plays a pivotal role in signaling pathways regulating cellular responses to stress, apoptosis, inflammation, and proliferation. MAP3K11 activates downstream kinases like JNK and p38 MAPK through phosphorylation, often in response to cytokines, growth factors, or cellular damage. Structurally, it contains a kinase domain, a leucine zipper motif, and an SH3-binding motif, enabling interactions with adaptor proteins and scaffolding complexes.

Antibodies targeting MAP3K11 are widely used in Western blotting, immunoprecipitation, and immunohistochemistry to detect protein expression, localization, and activation states in tissues or cultured cells. They are essential for investigating MAP3K11's involvement in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where its dysregulation is linked to tumor progression, insulin resistance, or neuronal death. Validated antibodies typically undergo specificity checks using knockout cell lines or siRNA-mediated knockdown. Researchers also utilize these antibodies to explore therapeutic targeting of MAP3K11. as its inhibition shows potential in modulating pathological signaling cascades. Host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) vary, allowing flexibility in experimental design.