TRPV1抗体;TRPV1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11941(TRPV1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11941(TRPV1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel, a non-selective cation channel activated by capsaicin, heat, protons, and lipid mediators, plays a critical role in nociception, thermosensation, and inflammatory pain signaling. TRPV1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunocytochemistry (ICC) to detect TRPV1 in tissues such as sensory neurons, epithelial cells, and the central nervous system.

Research involving TRPV1 antibodies has advanced understanding of pain mechanisms, neurogenic inflammation, and conditions like neuropathic pain, migraine, and cancer. Specificity is crucial, as TRPV1 shares structural homology with other TRP channels. Antibodies targeting distinct epitopes (e.g., N-terminal or transmembrane domains) help validate findings across species, including humans, rodents, and non-mammalian models.

Challenges include cross-reactivity or batch variability, necessitating rigorous validation via knockout controls or peptide-blocking assays. Despite this, TRPV1 antibodies remain pivotal in drug discovery, particularly for developing analgesics targeting TRPV1 pathways. Their application extends to studying TRPV1 modulation by inflammatory mediators, pH changes, or small-molecule inhibitors, highlighting their versatility in both basic and translational research.