ME1抗体;ME1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, A431 cells, Primary antibody: P11936(ME1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P11936(ME1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11936(ME1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

ME1 (Malic Enzyme 1) antibody targets the NADP-dependent malic enzyme, a key metabolic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate, generating NADPH. This enzyme plays a critical role in cellular energy metabolism, lipid synthesis, and redox balance by supplying NADPH, a cofactor essential for biosynthetic pathways and antioxidant defense. ME1 is expressed in various tissues, including the liver, adipose tissue, and certain cancers, where its dysregulation has been linked to metabolic disorders, tumor progression, and chemoresistance.

In research, ME1 antibodies are widely used to study its expression patterns, subcellular localization, and functional roles in physiological and pathological contexts. For example, elevated ME1 levels have been associated with poor prognosis in cancers like hepatocellular carcinoma and breast cancer, suggesting its potential as a therapeutic target or biomarker. These antibodies are employed in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ME1's involvement in metabolic reprogramming, oxidative stress responses, and cancer cell survival.

ME1 antibodies are typically validated for specificity across human, mouse, and rat samples, aiding cross-species studies. Their development and application continue to advance understanding of metabolic diseases and cancer biology, highlighting ME1's dual role as a metabolic enzyme and a regulator of cellular adaptation.