MCHR1抗体;MCHR1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human placenta tissue, Human testis tissue, Primary antibody: P11934(MCHR1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11934(MCHR1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11934(MCHR1 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

Melanin-concentrating hormone receptor 1 (MCHR1) is a G protein-coupled receptor predominantly expressed in the central nervous system, particularly in regions involved in energy homeostasis, appetite regulation, and emotional processing, such as the hypothalamus and limbic system. It binds melanin-concentrating hormone (MCH), a neuropeptide critical in modulating feeding behavior, energy balance, and stress responses. MCHR1 has garnered significant research interest due to its potential role in metabolic disorders, obesity, and mood-related conditions.

Antibodies targeting MCHR1 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques like immunohistochemistry, Western blotting, and flow cytometry to map receptor distribution in tissues or assess changes in expression under experimental conditions (e.g., dietary interventions or genetic models). Developing specific and reliable MCHR1 antibodies has been challenging due to the receptor’s structural homology with other GPCRs and low endogenous expression levels. Validated antibodies enable researchers to explore MCHR1’s signaling mechanisms, its interaction with ligands, and its relevance to diseases. Despite early drug development efforts targeting MCHR1 for obesity treatment (largely discontinued due to side effects), ongoing research continues to investigate its therapeutic potential, underscoring the importance of high-quality antibodies in preclinical studies.