MAGEL2抗体;MAGEL2 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P11924(MAGEL2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 40 seconds    

  
  

The MAGEL2 antibody targets the protein encoded by the *MAGEL2* gene, a member of the MAGE (melanoma antigen) gene family located within the Prader-Willi syndrome (PWS) critical region on chromosome 15q11-q13. MAGEL2 is a maternally imprinted, paternally expressed gene involved in neurodevelopment, circadian rhythm regulation, and cellular trafficking. It plays a critical role in the pathogenesis of Prader-Willi syndrome and Schaaf-Yang syndrome, both neurodevelopmental disorders characterized by hypotonia, intellectual disability, and behavioral abnormalities. MAGEL2 interacts with proteins in the ubiquitination pathway, including TRIM27 and USP7. suggesting roles in protein degradation and post-translational modification.

Antibodies against MAGEL2 are primarily used in research to study its expression patterns, subcellular localization, and interactions in neuronal tissues or model systems. Immunohistochemistry (IHC), Western blot (WB), and immunofluorescence (IF) are common applications. Dysregulation of MAGEL2 is also implicated in cancer, though its oncogenic mechanisms remain less defined. Commercially available MAGEL2 antibodies are typically validated for specificity using knockout controls or siRNA knockdown to ensure accurate detection. Understanding MAGEL2's function through antibody-based assays contributes to insights into imprinting disorders, neurodevelopmental pathways, and potential therapeutic targets.