GPAT3抗体;GPAT3 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 80 μg, Lane: Humna placenta tissue, Primary antibody: P11917(GPAT3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11917(GPAT3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11917(GPAT3 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The glycerol-3-phosphate acyltransferase 3 (GPAT3) is a key enzyme in glycerolipid biosynthesis, catalyzing the initial acylation of glycerol-3-phosphate to form lysophosphatidic acid. This step is critical for the synthesis of triglycerides and phospholipids, essential components of cellular membranes and lipid storage. GPAT3. one of four GPAT isoforms (GPAT1-4), is primarily localized to the endoplasmic reticulum and highly expressed in tissues with active lipid metabolism, such as the liver, adipose tissue, and intestine. It plays a role in regulating lipid homeostasis and has been implicated in metabolic disorders, including obesity, insulin resistance, and hepatic steatosis. Studies suggest GPAT3 prefers unsaturated fatty acyl-CoA substrates, influencing membrane lipid composition and signaling pathways.

GPAT3-specific antibodies are vital tools for investigating its expression, localization, and function. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research on its regulatory mechanisms in metabolic diseases. Recent work highlights GPAT3’s potential as a therapeutic target, with its inhibition showing promise in mitigating diet-induced metabolic dysfunction. However, isoform-specific antibody validation remains crucial due to structural similarities among GPAT family members. These antibodies help clarify GPAT3’s distinct roles in lipid metabolism and disease pathogenesis, advancing our understanding of lipid-related health conditions.