SCGB1D2抗体;SCGB1D2 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11904(SCGB1D2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11904(SCGB1D2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

SCGB1D2. a member of the secretoglobin family, is a small secreted protein encoded by the SCGB1D2 gene located on human chromosome 11. Secretoglobins are characterized by their compact structure stabilized by disulfide bonds and involvement in modulating inflammation, immune responses, and steroid signaling. SCGB1D2 is primarily expressed in epithelial tissues, including respiratory, urogenital, and mammary glands, though its precise biological function remains unclear. Studies suggest potential roles in maintaining mucosal barrier integrity, regulating lipid metabolism, or interacting with hydrophobic ligands.

Antibodies targeting SCGB1D2 have emerged as valuable tools for investigating its expression patterns and functional mechanisms. These antibodies are typically developed using recombinant SCGB1D2 protein or peptide immunogens, with validation in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence. Commercial antibodies often specify reactivity across human, mouse, or rat samples. Researchers have utilized SCGB1D2 antibodies to explore its dysregulation in diseases, particularly cancers such as breast and prostate cancer, where altered expression may correlate with tumor progression. However, cross-reactivity with structurally similar secretoglobin family members (e.g., SCGB1A1. SCGB3A2) remains a technical challenge, necessitating careful validation via knockout controls. Recent studies also investigate SCGB1D2's potential as a diagnostic biomarker in bodily fluids, driving demand for high-specificity antibodies in clinical assay development.