LEO1抗体;LEO1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11902(LEO1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11902(LEO1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The LEO1 (Left Open Reading Frame 1) antibody is a tool used to study the LEO1 protein, a key component of the RNA polymerase II-associated factor 1 (PAF1) complex. This complex is evolutionarily conserved and plays a critical role in transcriptional elongation, histone modification, and chromatin remodeling. LEO1. along with other PAF1 members (e.g., PAF1. CTR9. CDC73. RTF1), interacts with RNA polymerase II to regulate gene expression by facilitating the recruitment of histone-modifying enzymes, such as those involved in H2B ubiquitination and H3K4 methylation. These processes influence transcriptional fidelity, mRNA stability, and epigenetic regulation.

LEO1 is implicated in diverse cellular functions, including stem cell maintenance, development, and oncogenesis. Dysregulation of the PAF1 complex has been linked to cancers, developmental disorders, and viral replication. The LEO1 antibody is widely used in research to investigate its role in these pathways through techniques like Western blotting, chromatin immunoprecipitation (ChIP), and immunofluorescence. It helps identify LEO1-protein interactions, map genomic binding sites, and assess its expression levels in disease models. As a reagent, the antibody’s specificity and reliability are critical for elucidating mechanistic insights into transcriptional regulation and potential therapeutic targets.