ANP32E抗体;ANP32E Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse thymus tissue, Primary antibody: P11893(ANP32E Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11893(ANP32E Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11893(ANP32E Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

ANP32E (Acidic Nuclear Phosphoprotein 32 Family Member E) is a member of the ANP32 protein family, characterized by their acidic regions and leucine-rich repeats. These proteins play diverse roles in chromatin remodeling, transcriptional regulation, and apoptosis. ANP32E specifically interacts with histone H2A.Z, a histone variant involved in epigenetic regulation, and facilitates its removal from nucleosomes through the chaperone activity of SRCAP (SNF2-related CREBBP activator protein). This interaction is critical for maintaining chromatin dynamics and gene expression patterns, particularly during cellular differentiation and stress responses.

Antibodies targeting ANP32E are essential tools for studying its expression, localization, and function in various biological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore ANP32E's role in cancer, neurodevelopment, and epigenetic regulation. Studies have linked ANP32E dysregulation to tumor progression, as it may act as an oncogene or tumor suppressor depending on cellular context. For instance, elevated ANP32E levels correlate with poor prognosis in certain cancers, while its depletion can impair DNA repair and cell proliferation.

Researchers also utilize ANP32E antibodies to investigate its involvement in histone H2A.Z deposition, chromatin accessibility, and interactions with other epigenetic modifiers. These studies provide insights into diseases linked to chromatin instability, such as neurodegeneration and developmental disorders. Validated antibodies with high specificity are crucial for distinguishing ANP32E from homologous family members, ensuring accurate experimental outcomes.