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网站主页 KIF22 antibody KIF22抗体
  • KIF22抗体;KIF22 Antibody—艾普蒂
  • KIF22抗体;KIF22 Antibody—艾普蒂
  • KIF22抗体;KIF22 Antibody—艾普蒂

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KIF22抗体;KIF22 Antibody—艾普蒂

Rabbit Polyclonal KIF22 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
KIF22抗体
英文名称：
Rabbit Polyclonal KIF22 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6322 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
KIF22

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesKID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2
WB Predicted band size73 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KIF22
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A431 cells, MCF7 cells, Hela cells, Primary antibody: P11881(KIF22 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11881(KIF22 Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11881(KIF22 Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是关于KIF22抗体的3篇参考文献及其摘要概括：

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1. **文献名称**：*KIF22 promotes progression of osteosarcoma by activating the MEK/ERK pathway*

**作者**：Li Y, et al.

**摘要**：该研究利用KIF22抗体进行免疫组化分析，发现KIF22在骨肉瘤组织中高表达，并通过激活MEK/ERK信号通路促进肿瘤细胞增殖和迁移。实验表明，敲低KIF22可抑制体内外肿瘤生长。

2. **文献名称**：*KIF22 as a prognostic biomarker in hepatocellular carcinoma: Insights from antibody-based expression profiling*

**作者**：Wang X, et al.

**摘要**：研究者通过KIF22抗体检测肝细胞癌(HCC)患者样本，发现KIF22高表达与患者不良预后显著相关。机制研究表明，KIF22通过调控细胞周期蛋白加速肿瘤进展。

3. **文献名称**：*KIF22 regulates mitotic progression by interacting with centromere-associated proteins*

**作者**：Tanaka H, et al.

**摘要**：该研究利用KIF22抗体进行免疫荧光定位，揭示KIF22在有丝分裂中与着丝粒蛋白相互作用，确保染色体正确分离。功能实验表明，KIF22缺失会导致染色体错配和细胞周期停滞。

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以上文献均通过KIF22抗体探究其在癌症或细胞分裂中的功能，可作为相关研究的参考。如需具体文献来源，建议通过PubMed或ResearchGate检索标题获取全文。

       

背景信息

The KIF22 antibody is a crucial tool for studying the kinesin family member 22 (KIF22), a motor protein belonging to the kinesin-4 subfamily. KIF22 plays a key role in mitotic processes, particularly in regulating chromosome alignment and spindle dynamics during cell division. It interacts with microtubules and contributes to their stability and organization, ensuring accurate segregation of genetic material. Dysregulation of KIF22 has been linked to genomic instability and cancer progression, with overexpression observed in malignancies like osteosarcoma, hepatocellular carcinoma, and glioblastoma, where it correlates with poor prognosis and aggressive phenotypes.

KIF22 antibodies are widely used in biomedical research to detect protein expression levels, localization, and functional interactions in cellular and tissue samples. These antibodies are essential for techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Validated for specificity, they help elucidate KIF22's role in tumorigenesis, metastasis, and therapeutic resistance. Recent studies also explore KIF22 as a potential diagnostic biomarker or therapeutic target, particularly in cancers with chromosomal instability. Researchers rely on high-quality KIF22 antibodies to investigate its molecular mechanisms and evaluate its clinical relevance in precision medicine approaches.

       
KIF22抗体;KIF22;KIF22 Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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