KCNMB4抗体;KCNMB4 Antibody—艾普蒂

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     Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P11878(KCNMB4 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11878(KCNMB4 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11878(KCNMB4 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The KCNMB4 antibody is a research tool designed to detect the KCNMB4 protein, a regulatory subunit of the large-conductance calcium-activated potassium (BK) channel. Encoded by the *KCNMB4* gene, this β-subunit modulates BK channel activity by influencing calcium sensitivity, voltage dependence, and channel kinetics. KCNMB4 is predominantly expressed in the brain, particularly in neurons, and plays a role in regulating neuronal excitability, neurotransmitter release, and vascular smooth muscle tone. Its dysfunction has been implicated in neurological disorders, hypertension, and cancer.

The antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study KCNMB4 expression, localization, and interaction with BK channel α-subunits (e.g., KCNMA1). Researchers employ it to explore tissue-specific roles of KCNMB4. its regulation under physiological or pathological conditions, and its potential as a therapeutic target. Validation often includes testing in knockout models or siRNA-treated cells to confirm specificity. Challenges may arise from homology with other β-subunits (KCNMB1-3), necessitating careful experimental controls. Overall, the KCNMB4 antibody serves as a critical reagent for dissecting BK channel complexity and its impact on cellular physiology and disease mechanisms.