SYN2抗体;SYN2 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P11853(SYN2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11853(SYN2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11853(SYN2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

Synapsin II (SYN2), a member of the synapsin protein family, is primarily expressed in neuronal presynaptic terminals and plays a critical role in regulating synaptic vesicle trafficking, neurotransmitter release, and synaptic plasticity. It interacts with both synaptic vesicles and cytoskeletal components, modulating vesicle clustering, mobilization, and docking. SYN2 antibodies are essential tools for detecting and studying this protein's expression, localization, and function in neurological research.

These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SYN2's involvement in neurodevelopment, synaptic connectivity, and neurological disorders. Studies link SYN2 dysfunction to conditions such as schizophrenia, bipolar disorder, and Alzheimer's disease, with genetic variations in SYN2 associated with altered synaptic transmission. Additionally, SYN2 antibodies have helped elucidate its role in regulating axonal outgrowth, dendritic spine formation, and activity-dependent synaptic remodeling. Their application in disease models continues to advance understanding of synaptic pathophysiology and potential therapeutic targets. Validation via knockout controls ensures specificity, making SYN2 antibodies pivotal for exploring molecular mechanisms underlying synaptic maintenance and cognitive processes.