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  • IL17RB抗体;IL17RB Antibody—艾普蒂
  • IL17RB抗体;IL17RB Antibody—艾普蒂
  • IL17RB抗体;IL17RB Antibody—艾普蒂

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IL17RB抗体;IL17RB Antibody—艾普蒂

Rabbit Polyclonal IL17RB Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
IL17RB抗体
英文名称：
Rabbit Polyclonal IL17RB Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6298 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
IL17RB

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCRL4; EVI27; IL17BR; IL17RH1
WB Predicted band size56 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human IL17RB
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal liver tissue, Primary antibody: P11848(IL17RB Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11848(IL17RB Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11848(IL17RB Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3-4篇关于 **IL17RB抗体** 的参考文献示例(内容基于公开研究概括，非真实文献)：

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1. **文献名称**: *"Targeting IL17RB with a monoclonal antibody suppresses pancreatic cancer progression by inhibiting tumor-stroma crosstalk"*

**作者**: Chen et al.

**摘要**: 研究开发了一种靶向IL17RB的单克隆抗体，通过阻断IL17B/IL17RB信号轴，抑制胰腺癌细胞与肿瘤相关成纤维细胞的相互作用，显著减少小鼠模型中肿瘤生长和转移。

2. **文献名称**: *"IL17RB blockade attenuates allergic lung inflammation by modulating Th2 and innate lymphoid cell responses"*

**作者**: Smith et al.

**摘要**: 该文献证明抗IL17RB抗体可抑制IL-25(IL17RB配体)介导的Th2细胞和2型固有淋巴细胞(ILC2s)活化，减轻小鼠过敏性气道炎症，提示其在哮喘治疗中的潜力。

3. **文献名称**: *"Therapeutic targeting of IL17RB in inflammatory bowel disease through antibody-mediated neutralization"*

**作者**: Kim et al.

**摘要**: 研究利用人源化IL17RB抗体中和IL-17B/IL-17E信号，在小鼠结肠炎模型中减少肠道炎症细胞浸润和促炎因子分泌，验证了其作为炎症性肠病治疗策略的可行性。

4. **文献名称**: *"Structural characterization of IL17RB receptor and implications for antibody design"*

**作者**: Wang et al.

**摘要**: 通过解析IL17RB的晶体结构，研究者设计了高亲和力抗体，阻断配体结合位点，为开发针对IL17RB相关疾病的精准疗法提供结构生物学依据。

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注：以上为示例性内容，实际文献需通过数据库(如PubMed、Web of Science)检索确认。

       

背景信息

Interleukin-17 receptor B (IL17RB), a member of the IL-17 receptor family, is a cell surface protein involved in pro-inflammatory signaling and immune regulation. It binds primarily to IL-17B and IL-17E (IL-25), activating downstream pathways like NF-κB and MAPK, which drive cytokine production and immune cell recruitment. IL17RB is expressed on epithelial cells, immune cells (e.g., Th2. ILC2s), and certain cancer cells, linking it to allergic inflammation, autoimmune disorders, and tumor progression.

In diseases, IL17RB/IL-25 signaling promotes type 2 immunity, contributing to asthma, atopic dermatitis, and eosinophilic disorders. In oncology, IL17RB overexpression in pancreatic, breast, and liver cancers correlates with poor prognosis, enhancing tumor cell survival, angiogenesis, and metastasis. Targeting IL17RB with monoclonal antibodies (mAbs) has emerged as a therapeutic strategy. Preclinical studies show anti-IL17RB mAbs block ligand-receptor interactions, suppressing inflammation in asthma models and inhibiting tumor growth by disrupting pro-survival signals. Some antibodies also enhance chemotherapy efficacy in cancers.

Despite promise, clinical translation remains limited. Research focuses on optimizing antibody specificity, understanding receptor heterodimerization (e.g., with IL17RA), and balancing therapeutic effects against potential immune suppression risks. IL17RB antibodies represent a dual-purpose tool for modulating immune dysregulation and oncogenic signaling, though further validation in human trials is needed.

       
IL17RB抗体;IL17RB;IL17RB Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

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