HSPB6抗体;HSPB6 Antibody—艾普蒂

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Rat heart tissue and Human heart tissue lysates, Primary antibody: P11834(HSPB6 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11834(HSPB6 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11834(HSPB6 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The heat shock protein beta-6 (HSPB6), also known as HSP20. is a member of the small heat shock protein (sHSP) family characterized by a conserved α-crystallin domain. With a molecular weight of approximately 17 kDa, HSPB6 is ubiquitously expressed but enriched in smooth muscle, cardiac tissue, and skeletal muscle. It plays a regulatory role in stress response, cell survival, and cytoskeletal organization. Notably, HSPB6 is involved in modulating vascular relaxation through interactions with nitric oxide signaling pathways and exhibits cardioprotective effects by preventing apoptosis and improving contractile function under ischemic conditions. Dysregulation of HSPB6 has been linked to cardiovascular diseases, neurodegenerative disorders, and cancer, making it a target for therapeutic research.

HSPB6 antibodies are essential tools for detecting and quantifying this protein in experimental settings. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study HSPB6 expression, localization, and interactions under physiological or pathological conditions. Polyclonal antibodies offer broad epitope recognition, while monoclonal antibodies provide high specificity. Validated antibodies undergo rigorous testing for cross-reactivity, often using knockout cell lines or peptide blocking assays. Researchers rely on HSPB6 antibodies to explore its role in stress adaptation, disease mechanisms, and potential as a biomarker or therapeutic target.