HNRNPH1抗体;HNRNPH1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: LoVo cells, A375 cells, mouse brain tissue, HepG2 cells, A431 cells, Hela cells, Primary antibody: P11821(HNRNPH1 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

The HNRNPH1 antibody is a crucial tool for studying the heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), a member of the hnRNP family involved in RNA metabolism. HNRNPH1 plays a key role in pre-mRNA splicing, mRNA transport, stability, and translation by binding to specific RNA motifs, such as G-rich sequences. It is implicated in diverse cellular processes, including gene expression regulation and stress response. Dysregulation of HNRNPH1 has been linked to neurological disorders, cancer, and viral infections, highlighting its biomedical relevance.

HNRNPH1 antibodies are widely used in research to detect protein expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies help investigate HNRNPH1's functional roles in RNA processing and disease mechanisms. Specificity and validation are critical, as cross-reactivity with other hnRNP family members (e.g., HNRNPH2/H3) may occur due to structural similarities. Commercial HNRNPH1 antibodies are typically raised against recombinant protein fragments or synthetic peptides, with host species (e.g., rabbit, mouse) and clonality (monoclonal/polyclonal) varying by supplier. Recent studies also utilize these antibodies to explore HNRNPH1's involvement in alternative splicing in conditions like autism spectrum disorders and cancer progression, underscoring their utility in both basic and translational research.