HMGCS2抗体;HMGCS2 Antibody—艾普蒂

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P11818(HMGCS2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11818(HMGCS2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11818(HMGCS2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) is a mitochondrial enzyme critical for ketogenesis, the metabolic pathway producing ketone bodies as alternative energy sources during fasting or glucose scarcity. Primarily expressed in the liver, HMGCS2 catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA to form HMG-CoA, a key step in ketogenesis. Dysregulation of HMGCS2 is linked to metabolic disorders (e.g., diabetes, obesity), cancer (where altered ketone metabolism may support tumor growth), and neurological conditions influenced by energy metabolism.

HMGCS2 antibodies are essential tools for detecting and quantifying HMGCS2 protein levels in research. They enable investigations into tissue-specific expression, subcellular localization, and regulatory mechanisms under varying physiological or pathological conditions. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA. Commercial HMGCS2 antibodies are typically raised against specific epitopes (e.g., human HMGCS2 peptide sequences) and validated for cross-reactivity in species such as mouse, rat, and human.

Researchers rely on HMGCS2 antibodies to explore metabolic adaptations, cancer metabolism, and therapeutic targeting of ketogenic pathways. Validation via knockout controls or siRNA-mediated silencing ensures specificity, while applications extend to clinical studies assessing HMGCS2 as a biomarker in metabolic diseases or oncology. Reliable suppliers include Abcam, Cell Signaling Technology, and Santa Cruz Biotechnology, offering monoclonal or polyclonal formats for diverse experimental needs.