HIPK1抗体;HIPK1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11814(HIPK1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11814(HIPK1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of HIPK1 Antibody**

The Homeodomain-Interacting Protein Kinase 1 (HIPK1) is a serine/threonine kinase belonging to the HIPK family, which includes HIPK2. HIPK3. and HIPK4. HIPK1 plays a regulatory role in diverse cellular processes, including transcriptional regulation, apoptosis, DNA damage response, and cellular stress signaling. It interacts with transcription factors, such as homeodomain proteins, p53. and Wnt pathway components, modulating their activity through phosphorylation. HIPK1 is implicated in developmental processes, cancer (acting as a tumor suppressor or promoter depending on context), and neurodegenerative diseases.

HIPK1 antibodies are essential tools for detecting and studying the expression, localization, and function of HIPK1 in biological samples. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate HIPK1’s role in signaling pathways and disease mechanisms. Specificity and validation of these antibodies are critical, as HIPK1 shares structural homology with other HIPK family members. Research utilizing HIPK1 antibodies has advanced understanding of its dual roles in cell survival/death decisions and its potential as a therapeutic target in pathologies like cancer and neurodegeneration.