GPR65抗体;GPR65 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P11804(GPR65 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11804(GPR65 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

GPR65. also known as TDAG8 (T-cell death-associated gene 8), is a pH-sensing G protein-coupled receptor (GPCR) that plays a role in immune regulation and inflammatory responses. It is activated under acidic conditions, such as those found in inflamed or tumor microenvironments, and signals through Gαs-mediated pathways to modulate intracellular cAMP levels. GPR65 is expressed in immune cells, including T cells, macrophages, and dendritic cells, where it influences processes like cytokine production, apoptosis, and immune cell migration. Dysregulation of GPR65 has been linked to inflammatory diseases (e.g., inflammatory bowel disease, asthma) and cancer progression.

Antibodies targeting GPR65 are critical tools for studying its expression, localization, and function. They enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry. These antibodies are also used to explore GPR65's role in pH-dependent signaling and its potential as a therapeutic target. Commercial GPR65 antibodies vary in specificity, with validation often including knockout cell lines or tissues to confirm minimal cross-reactivity. Recent research highlights GPR65's dual role in promoting inflammation or immunosuppression, depending on context, making its study vital for understanding disease mechanisms and developing targeted therapies.