GNPAT抗体;GNPAT Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11797(GNPAT Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11797(GNPAT Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The GNPAT (glyceronephosphate O-acyltransferase) antibody is a tool used to detect and study the GNPAT protein, a key enzyme in the biosynthesis of plasmalogens—a class of ether phospholipids critical for cell membrane structure, signaling, and organelle function. GNPAT catalyzes the first committed step in plasmalogen synthesis, transferring an acyl group to glyceronephosphate within peroxisomes. Plasmalogens are particularly abundant in tissues with high metabolic activity, such as the brain, heart, and immune cells, and their deficiency is linked to peroxisomal disorders like rhizomelic chondrodysplasia punctata (RCDP) and neurodegenerative diseases.

Research involving GNPAT antibodies focuses on understanding its role in lipid metabolism, peroxisomal function, and disease mechanisms. Mutations in the GNPAT gene are associated with RCDP type 2. a rare genetic disorder characterized by skeletal abnormalities, cataracts, and developmental delays. The antibody is utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and dysregulation in disease models or clinical samples. Additionally, it aids in exploring GNPAT's involvement in oxidative stress responses and its potential crosstalk with metabolic pathways. As plasmalogens are increasingly implicated in neuroprotection and lipid homeostasis, GNPAT antibodies serve as vital reagents for both basic research and diagnostic investigations targeting peroxisome-related pathologies.