GAS8抗体;GAS8 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11781(GAS8 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11781(GAS8 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The Growth Arrest-Specific 8 (GAS8) gene encodes a protein involved in cellular processes such as ciliary function, cell motility, and signaling pathways. It belongs to the GAS gene family, initially identified for their upregulation during growth arrest. The GAS8 protein interacts with the microtubule-associated Nexin-Dynein regulatory complex, playing a critical role in the structure and function of motile cilia and flagella. Dysregulation of GAS8 has been linked to primary ciliary dyskinesia (PCD), particularly subtype PCD2. characterized by impaired ciliary movement and respiratory/fertility issues.

GAS8 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate GAS8's role in ciliopathies, cancer, and cellular signaling. For instance, reduced GAS8 expression has been observed in certain cancers, suggesting tumor-suppressive functions. Commercially available antibodies target specific epitopes, but validation is crucial due to potential cross-reactivity with homologous proteins or isoforms.

Recent studies highlight GAS8's involvement in Hedgehog signaling and its potential as a biomarker. However, challenges remain in standardizing antibody specificity across experimental models. Research using GAS8 antibodies continues to uncover its mechanistic contributions to diseases, emphasizing its importance in both basic and clinical contexts.