GAS1抗体;GAS1 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, human kidney tissue, Primary antibody: P11780(GAS1 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11780(GAS1 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The Growth Arrest-Specific 1 (GAS1) protein is a cell membrane-associated molecule initially identified in fibroblasts during growth arrest. It plays a critical role in regulating cell proliferation, differentiation, and survival, primarily by modulating key signaling pathways such as Hedgehog (Hh) and glial cell line-derived neurotrophic factor (GDNF) signaling. GAS1 acts as a co-receptor, enhancing Hh pathway activity by binding to the receptor Patched-1 (PTCH1), while paradoxically inhibiting GDNF signaling by interfering with the RET receptor tyrosine kinase. Its dual regulatory function makes it pivotal in embryonic development, tissue homeostasis, and cancer progression.

GAS1 antibodies are essential tools for detecting and studying the expression, localization, and functional roles of GAS1 in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate GAS1's involvement in neurodevelopment, organogenesis, and diseases such as cancer, where its expression is often dysregulated. Research has also explored GAS1's potential as a therapeutic target, particularly in tumors reliant on Hh or GDNF signaling. However, its context-dependent roles—acting as either a tumor suppressor or promoter—highlight the need for precise characterization using specific antibodies to unravel its complex biological mechanisms.