FGF20抗体;FGF20 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11764(FGF20 Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

Fibroblast Growth Factor 20 (FGF20) is a member of the FGF family, which comprises 22 proteins involved in cell proliferation, differentiation, and tissue repair. FGF20. specifically, plays critical roles in embryonic development, tissue homeostasis, and repair. It is highly expressed in the central nervous system, kidneys, and hair follicles, and has been implicated in neuroprotection, wound healing, and hair growth regulation. Dysregulation of FGF20 is linked to neurodegenerative disorders (e.g., Parkinson’s disease) and cancers (e.g., colorectal and hepatocellular carcinoma).

FGF20 antibodies are essential tools for studying its expression, localization, and function. These antibodies, typically monoclonal or polyclonal, are designed to bind specifically to FGF20 epitopes, enabling detection via techniques like Western blotting, immunohistochemistry, and ELISA. They help elucidate FGF20's interaction with its receptor FGFRs and co-receptors like heparan sulfate, as well as its downstream signaling pathways (e.g., MAPK/ERK, PI3K/AKT).

Research using FGF20 antibodies has highlighted its therapeutic potential. For instance, in Parkinson’s disease models, FGF20 promotes dopaminergic neuron survival, suggesting neuroprotective applications. In oncology, FGF20 antibodies aid in exploring its role in tumor progression and as a biomarker. Additionally, they are investigated in dermatology for hair regeneration therapies. However, challenges remain in optimizing antibody specificity and minimizing cross-reactivity with homologous FGFs. Overall, FGF20 antibodies are pivotal in advancing both basic research and clinical translation.