FGF16抗体;FGF16 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11762(FGF16 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P11762(FGF16 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of FGF16 Antibody**

Fibroblast Growth Factor 16 (FGF16) is a member of the FGF family, which comprises 23 secreted signaling proteins involved in cell proliferation, differentiation, tissue repair, and embryonic development. FGF16. part of the FGF8 subfamily, is primarily expressed during embryogenesis, particularly in the developing heart, brain, and skeletal tissues. It interacts with FGF receptors (FGFRs) and heparan sulfate proteoglycans to regulate signaling pathways like MAPK and PI3K-AKT, influencing organogenesis and tissue homeostasis.

FGF16 antibodies are essential tools for detecting and studying this protein's expression, localization, and function. They enable techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate FGF16's role in developmental biology and disease. Research links FGF16 to cardiac development, limb formation, and carcinogenesis, with aberrant expression observed in certain cancers (e.g., breast and prostate) and heart conditions.

Commercial FGF16 antibodies are typically raised in rabbits or mice, often validated for specificity using knockout controls or recombinant proteins. Their applications extend to mechanistic studies, biomarker discovery, and therapeutic targeting. However, challenges like cross-reactivity with homologous FGFs (e.g., FGF8/17/18) necessitate rigorous validation. Continued research on FGF16 antibodies may advance understanding of developmental disorders and cancer, potentially guiding diagnostic or therapeutic innovations.

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