AMER1抗体;AMER1 Antibody—艾普蒂

+ +

•  

   

     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11755(AMER1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11755(AMER1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The AMER1 (APC Membrane Recruitment Protein 1) antibody is a tool used to study the AMER1 protein, encoded by the *AMER1* gene (also known as *WTX* or *FAM123B*). AMER1 is a tumor suppressor involved in the Wnt/β-catenin signaling pathway, a critical regulator of cell proliferation and differentiation. It functions by recruiting the β-catenin destruction complex to the cell membrane, promoting β-catenin degradation and thus inhibiting Wnt signaling. Mutations or deletions in *AMER1* are linked to Wilms' tumor, a pediatric kidney cancer, and somatic mutations are observed in colorectal and other cancers, contributing to tumorigenesis through dysregulated Wnt activity.

AMER1 antibodies are widely used in research to detect AMER1 expression and localization in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate AMER1's role in cancer biology, particularly its tumor-suppressive mechanisms and interactions with signaling partners like APC (adenomatous polyposis coli) and β-catenin. Clinically, AMER1 antibody-based assays may aid in diagnosing cancers with AMER1 alterations or assessing prognostic significance. However, its utility in therapeutic applications remains exploratory. Research continues to define AMER1's broader functional networks and potential as a biomarker or target in Wnt-driven malignancies.