ESPL1抗体;ESPL1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11746(ESPL1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11746(ESPL1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The ESPL1 antibody is a crucial tool in studying Separase, an enzyme encoded by the **ESPL1** gene, which plays a pivotal role in cell division. Separase, a cysteine protease, is essential for the metaphase-to-anaphase transition during mitosis and meiosis. Its primary function involves cleaving **cohesin complexes** that hold sister chromatids together, enabling their separation and ensuring accurate chromosome segregation. Dysregulation of ESPL1 activity is linked to **chromosomal instability**, a hallmark of cancer and developmental disorders.

ESPL1 antibodies are widely used in research to investigate Separase expression, localization, and activity across cell cycle stages. They facilitate techniques like **Western blotting**, **immunofluorescence**, and **immunohistochemistry**, aiding in the study of cell cycle regulation, cancer biology, and potential therapeutic targets. Additionally, these antibodies help assess post-translational modifications (e.g., phosphorylation) and interactions with regulatory proteins like **securin** and components of the **anaphase-promoting complex/cyclosome (APC/C)**.

Research using ESPL1 antibodies has revealed its dual role in tumorigenesis: while overexpression correlates with genomic instability in cancers, targeted inhibition of Separase shows promise in limiting tumor growth. Furthermore, ESPL1 variants are studied in reproductive health due to their impact on gametogenesis. Overall, ESPL1 antibodies serve as vital reagents in unraveling mechanisms of chromosome dynamics and developing strategies to combat diseases driven by mitotic errors.