DAAM1抗体;DAAM1 Antibody—艾普蒂

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     Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, 293T cells, Primary antibody: P11701(DAAM1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11701(DAAM1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11701(DAAM1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

DAAM1 (Dishevelled Associated Activator of Morphogenesis 1) is a formin-family protein involved in cytoskeletal reorganization and Wnt signaling pathways. It interacts with Dishevelled (Dvl) proteins to regulate actin dynamics, impacting cell polarity, migration, and tissue morphogenesis. DAAM1 is crucial in the planar cell polarity (PCP) pathway, a Wnt-mediated signaling cascade essential for embryonic development, organogenesis, and neural tube closure. It bridges membrane receptors and cytoskeletal effectors, facilitating actin polymerization and microtubule stabilization during processes like convergent extension in gastrulation.

DAAM1 antibodies are research tools designed to detect and quantify DAAM1 expression in cellular and tissue samples. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to study DAAM1's localization, interaction partners, and functional roles. These antibodies have been instrumental in linking DAAM1 dysregulation to pathological conditions, including cancer metastasis, neurodevelopmental disorders, and ciliopathies. For example, elevated DAAM1 expression correlates with invasive tumor behavior, while mutations are associated with neural tube defects. Researchers also employ DAAM1 antibodies to explore its crosstalk with other signaling pathways, such as Rho GTPase signaling, and its influence on stem cell differentiation. Available as polyclonal or monoclonal variants, these antibodies are typically validated in model organisms like mice, zebrafish, and human cell lines, aiding mechanistic studies in developmental biology and disease pathogenesis.