CYP2B6抗体;CYP2B6 Antibody—艾普蒂

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human colon cancer tissue, Primary antibody: P11700(CYP2B6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11700(CYP2B6 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The CYP2B6 antibody is a critical tool for studying the cytochrome P450 2B6 enzyme, a member of the P450 superfamily involved in metabolizing various xenobiotics and endogenous compounds. CYP2B6 is primarily expressed in the liver and plays a significant role in the oxidative metabolism of drugs, including antiretrovirals (e.g., efavirenz), chemotherapeutic agents (e.g., cyclophosphamide), and anesthetics (e.g., propofol). Its activity is influenced by genetic polymorphisms, leading to interindividual variability in drug metabolism, efficacy, and toxicity.

CYP2B6 antibodies are designed to detect and quantify the enzyme in biological samples, enabling researchers to investigate its expression, localization, and regulation. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study CYP2B6's role in drug interactions, tissue-specific expression, and disease associations. For instance, altered CYP2B6 levels have been linked to cancer progression, neurotoxicity, and resistance to therapies.

The development of specific and high-affinity CYP2B6 antibodies has advanced pharmacogenomic research, particularly in understanding how genetic variants (e.g., *CYP2B6*6) affect enzyme function. Such insights are crucial for personalized medicine, aiding in dose optimization and minimizing adverse drug reactions. Additionally, these antibodies support preclinical studies evaluating drug-induced CYP2B6 induction or inhibition, contributing to safer drug development. Overall, CYP2B6 antibodies are indispensable for unraveling the enzyme's complex roles in pharmacology and toxicology.