CSTB抗体;CSTB Antibody—艾普蒂

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     Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse spleen tissue, Primary antibody: P11698(CSTB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2.5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P11698(CSTB Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P11698(CSTB Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

CSTB (Cystatin B) is a small, ubiquitously expressed protein belonging to the cystatin superfamily of cysteine protease inhibitors. It primarily regulates the activity of lysosomal cathepsins, enzymes involved in protein degradation, by binding to their active sites. Dysregulation of CSTB has been linked to several pathological conditions, most notably Unverricht-Lundborg disease (EPM1), a rare inherited progressive myoclonus epilepsy caused by mutations in the CSTB gene. Loss-of-function mutations lead to reduced CSTB levels, resulting in uncontrolled protease activity, neuroinflammation, and neuronal apoptosis.

CSTB antibodies are essential tools in studying its expression, localization, and functional roles. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess CSTB protein levels in tissues or cell cultures, particularly in neurological research. These antibodies help elucidate mechanisms underlying EPM1 and other disorders associated with CSTB dysfunction, such as cancer and neurodegenerative diseases. Commercial CSTB antibodies are typically raised against specific epitopes of human CSTB and validated for cross-reactivity in model organisms like mice and rats. Recent studies also explore CSTB's non-canonical roles, including its involvement in autophagy and oxidative stress response, further highlighting the antibody's utility in diverse research contexts.