CSMD1抗体;CSMD1 Antibody—艾普蒂

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     The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P11689(CSMD1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P11689(CSMD1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

The CSMD1 (CUB and Sushi Multiple Domains 1) antibody is a tool used to study the CSMD1 protein, encoded by the CSMD1 gene located on human chromosome 8p23. CSMD1 is a large transmembrane protein belonging to the complement control protein (CCP) family, characterized by multiple CUB and sushi domains. It is implicated in regulating complement activation, cell adhesion, and proliferation, with potential tumor-suppressive roles in various cancers, including gliomas, head and neck squamous cell carcinoma, and colorectal cancer. Dysregulation of CSMD1 has also been linked to neuropsychiatric disorders like schizophrenia and Alzheimer’s disease.

CSMD1 antibodies are primarily used in research to detect protein expression and localization via techniques such as immunohistochemistry (IHC), Western blotting (WB), and immunofluorescence (IF). These studies help elucidate CSMD1’s involvement in cellular processes and disease mechanisms. For instance, reduced CSMD1 expression in tumors correlates with poor prognosis, suggesting its role in inhibiting metastasis and promoting apoptosis. However, challenges persist in antibody development due to CSMD1’s complex structure, multiple splice variants, and low endogenous expression levels, which can affect specificity and reproducibility. Despite these hurdles, CSMD1 antibodies remain critical for exploring its biological functions and clinical relevance.