COG1抗体;COG1 Antibody—艾普蒂

The COG1 antibody is a tool used to study the Conserved Oligomeric Golgi (COG) complex, a critical component in maintaining Golgi apparatus structure and function. The COG complex, composed of eight subunits (COG1-8), is divided into two subcomplexes: COG1-4 (subcomplex A) and COG5-8 (subcomplex B). COG1. a core subunit of subcomplex A, plays a pivotal role in vesicle tethering and retrograde trafficking within the Golgi, ensuring proper glycosylation, protein sorting, and organelle homeostasis. Dysregulation of COG1 is linked to congenital disorders of glycosylation (CDGs), such as CDG-II, characterized by impaired protein and lipid glycosylation. COG1 antibodies are widely employed in research to investigate Golgi dynamics, protein trafficking defects, and disease mechanisms. These antibodies enable detection of COG1 expression, localization, and interactions via techniques like Western blot, immunofluorescence, and immunoprecipitation. Studies using COG1 antibodies have revealed its involvement in neurological disorders and cancer, highlighting its broader biomedical relevance. By elucidating COG1's molecular interactions, researchers aim to uncover therapeutic targets for Golgi-related pathologies.