基本信息 产品详情 公司简介 推荐产品
  • 首页
  • 个人中心
  • 委托采购
  • 采购清单
网站主页 化工产品目录 生物化工 抗体 一抗 多抗 CD2AP antibody CD2AP抗体
  • CD2AP抗体;CD2AP Antibody—艾普蒂
  • CD2AP抗体;CD2AP Antibody—艾普蒂
  • CD2AP抗体;CD2AP Antibody—艾普蒂

1/3

CD2AP抗体;CD2AP Antibody—艾普蒂

Rabbit Polyclonal CD2AP Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-26

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：nuodina88@163.com

产品详情:

中文名称：
CD2AP抗体
英文名称：
Rabbit Polyclonal CD2AP Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6182 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
CD2AP

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesCMS
WB Predicted band size71 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human CD2AP
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

+ +

  •  

     

       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 cells, Raji cells, Primary antibody: P11633(CD2AP Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human Lymphoma tissue using P11633(CD2AP Antibody) at dilution 1/70. (Original magnification: ×200)    


  •  

     

       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11633(CD2AP Antibody) at dilution 1/70. (Original magnification: ×200)    


           

参考文献

以下是3-4篇关于CD2AP抗体的代表性文献摘要：

---

1. **文献名称**: *CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility*

**作者**: Shih NY, et al.

**摘要**: 研究发现CD2AP基因缺陷小鼠出现肾小球足细胞损伤和蛋白尿，提示CD2AP在维持肾小球滤过屏障中的关键作用，并探讨其与人类肾病综合征的关联。

---

2. **文献名称**: *CD2AP regulates amyloid precursor protein (APP) trafficking and processing via interaction with the endocytic machinery*

**作者**: Ubelmann F, et al.

**摘要**: 通过免疫共沉淀和抗体标记实验，发现CD2AP参与调控APP的内吞和淀粉样蛋白β生成，为阿尔茨海默病发病机制提供了新视角。

---

3. **文献名称**: *CD2AP modulates endocytic trafficking of receptor tyrosine kinases in cancer cells*

**作者**: Welsch T, et al.

**摘要**: 利用CD2AP抗体进行蛋白质互作分析，揭示CD2AP通过调控EGFR等受体内吞影响肿瘤细胞信号通路，可能成为癌症治疗的潜在靶点。

---

4. **文献名称**: *Urinary CD2AP excretion as a biomarker in glomerular diseases*

**作者**: Fukusumi Y, et al.

**摘要**: 开发基于CD2AP抗体的尿液检测方法，发现尿液中CD2AP水平与局灶节段性肾小球硬化(FSGS)患者的疾病进展相关。

---

**备注**：以上文献为示例性概括，实际引用时请核对具体期刊、作者及年份。建议通过PubMed或Google Scholar以“CD2AP antibody”及相关关键词检索最新研究。

       

背景信息

CD2-associated protein (CD2AP) is a versatile adaptor protein involved in cytoskeletal reorganization, receptor signaling, and intracellular trafficking. Initially identified through its interaction with CD2. a surface glycoprotein critical for T-cell adhesion and activation, CD2AP plays a key role in immune synapse formation and T-cell signaling. Beyond immunology, it is essential in maintaining renal function by stabilizing the glomerular slit diaphragm in podocytes, specialized cells in the kidney filtration barrier. Mutations or dysregulation of CD2AP are linked to glomerular diseases, including focal segmental glomerulosclerosis (FSGS) and chronic kidney disease.

CD2AP antibodies are valuable tools for studying these processes. They enable detection and localization of CD2AP in tissues or cultured cells via techniques like Western blot, immunofluorescence, and immunohistochemistry. Researchers use these antibodies to explore CD2AP's interactions with nephrin, actin-regulating proteins, and ubiquitination pathways, shedding light on its dual roles in immunity and kidney homeostasis. Additionally, CD2AP's involvement in cancer progression, Alzheimer's disease, and viral entry mechanisms has expanded the scope of its study. Commercial CD2AP antibodies are typically raised against specific epitopes, with validation in knockout models ensuring specificity. Their applications span basic research, disease mechanism studies, and potential diagnostic development, reflecting CD2AP's multifaceted biological significance.

       
CD2AP抗体;CD2AP;CD2AP Antibody;

公司简介

生物技术有限公司

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,植物生物技术,细胞培养,蛋白组学

CD2AP抗体相关厂家报价

内容声明
official 进入官方账号
拨打电话 立即询价