Transferrin抗体—艾普蒂

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     Western blot analysis of Transferrin expression in Human serum lysate.    

  
  

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     Immunohistochemical analysis of paraffin-embedded Human breast carcinoma, using Transferrin Antibody.    

  
  

Transferrin antibodies are essential tools in biomedical research and diagnostics, targeting transferrin, a glycoprotein responsible for iron transport in the blood. Transferrin binds to iron ions (Fe³⁺) in the bloodstream, facilitating their delivery to cells via transferrin receptor-mediated endocytosis. This process is critical for maintaining iron homeostasis, as iron is vital for numerous physiological functions, including oxygen transport and enzyme activity.

Antibodies against transferrin are widely used to study its expression, localization, and function in various tissues. Polyclonal and monoclonal transferrin antibodies enable detection in techniques like ELISA, Western blotting, and immunohistochemistry. They are particularly valuable in diagnosing and monitoring conditions associated with abnormal iron metabolism, such as iron-deficiency anemia, hereditary hemochromatosis, and chronic liver diseases. Additionally, transferrin levels in cerebrospinal fluid (CSF) serve as biomarkers for blood-brain barrier integrity, aiding in the assessment of neurological disorders.

In cancer research, transferrin antibodies help investigate overexpression of transferrin receptors in malignant cells, a feature exploited in targeted drug delivery systems. Recent studies also explore their role in neurodegenerative diseases, where iron accumulation is linked to pathologies like Alzheimer’s and Parkinson’s. Overall, transferrin antibodies remain indispensable for unraveling iron-related mechanisms and advancing therapeutic strategies.