RAIDD抗体—艾普蒂 新品

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     Western blot analysis of RAIDD expression in HeLa cell lysate.    

  
  

RAIDD (RIP-associated ICH-1/CED-3 homologous protein with a death domain) is an adaptor protein involved in apoptosis and inflammatory signaling pathways. It contains a C-terminal death domain (DD) and an N-terminal caspase recruitment domain (CARD), enabling interactions with other death domain-containing proteins like RIPK1 and caspase-2. RAIDD plays a critical role in assembling the PIDDosome complex (composed of PIDD, RAIDD, and caspase-2), which activates caspase-2 in response to DNA damage or cellular stress. This caspase-2 activation triggers downstream apoptotic cascades or NF-κB-mediated inflammatory responses, depending on cellular context.

RAIDD antibodies are essential tools for studying its expression, localization, and protein interactions in apoptosis regulation. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate RAIDD's role in diseases like cancer, neurodegenerative disorders, and autoimmune conditions. Some studies suggest RAIDD may act as a tumor suppressor by promoting apoptosis, while others implicate it in neuroinflammation pathways. Commercial RAIDD antibodies are typically raised against specific epitopes within its DD or CARD regions, with validation in knockout models to ensure specificity. Researchers also utilize these antibodies to explore post-translational modifications or alternative splicing variants of RAIDD that may influence its pro-apoptotic functions. Optimal antibody selection depends on experimental applications, as some isoforms or truncated forms may exhibit tissue-specific expression.