HSPA12A抗体—艾普蒂

+ +

•  

   

     Western blot analysis of HSPA12A expression in U-87 MG cell lysate.    

  
  

•  

   

     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

•  

   

     Immunohistochemical analysis of paraffin-embedded mouse brain, using HSPA12A Antibody.    

  
  

The HSPA12A antibody is a research tool designed to detect and analyze the Heat Shock Protein Family A (Hsp70) Member 12A, a less-characterized member of the Hsp70 protein family. Unlike canonical Hsp70 chaperones, HSPA12A lacks a conserved ATPase domain, suggesting distinct functional mechanisms. It is expressed in various tissues, with notable roles in endothelial cells and the nervous system. Studies link HSPA12A to cellular stress responses, anti-apoptotic signaling, and inflammatory regulation, particularly under pathological conditions such as ischemia-reperfusion injury, cardiovascular diseases, and neurodegenerative disorders. Its involvement in modulating pathways like PI3K/Akt and NF-κB highlights potential therapeutic relevance.

The antibody enables detection of HSPA12A via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its expression patterns and subcellular localization. However, specificity challenges arise due to sequence homology within the Hsp70 family, necessitating rigorous validation using knockout controls. Recent research also explores HSPA12A’s dual role in cancer, where it may act as either a tumor suppressor or promoter depending on context. As interest grows in its pathophysiological functions, the HSPA12A antibody remains critical for elucidating molecular mechanisms and validating biomarkers in disease models. Further studies are needed to clarify its interactions and therapeutic potential.