TMF抗体—艾普蒂 新品

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     Western blot analysis of TMF expression in HeLa cell lysate.    

  
  

**Background of TMF Antibody**

The TMF (TATA element modulatory factor) antibody targets a protein involved in transcriptional regulation and cellular processes. Initially identified as a co-regulator of transcription via interactions with the TATA-binding protein (TBP), TMF (also known as TATA-binding protein-associated factor 9. TAF9) plays roles in RNA polymerase II-mediated gene expression. Structurally, it contains conserved domains that facilitate binding to transcriptional machinery and chromatin-modifying complexes.

Research highlights TMF's involvement in diverse pathways, including cell cycle regulation, apoptosis, and response to DNA damage. Dysregulation of TMF has been linked to cancer progression, neurodegenerative diseases, and immune disorders. For instance, reduced TMF expression correlates with tumor aggressiveness in certain cancers, suggesting its role as a tumor suppressor.

TMF antibodies are widely used in molecular biology to study protein localization, expression levels, and interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation. Recent studies explore its potential as a biomarker for disease diagnosis or a therapeutic target. However, functional complexities, such as its dual roles in transcription activation and repression, warrant further investigation. The development of specific TMF antibodies continues to advance understanding of its molecular mechanisms and clinical relevance.