TorsinA抗体—艾普蒂 新品

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     All lanes use the Antibody at 1:1K dilution for 1 hour at room temperature.    

  
  

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     Western blot analysis of Torsin A expression in 293T cell lysate.    

  
  

**Background of TorsinA Antibodies**

TorsinA is a member of the AAA+ (ATPases Associated with Diverse Cellular Activities) protein family, characterized by its conserved ATPase domain. It is predominantly localized in the endoplasmic reticulum (ER) and nuclear envelope, where it plays roles in protein quality control, membrane trafficking, and cytoskeletal organization. Mutations in the *TOR1A* gene encoding TorsinA, particularly the ΔE302/303 deletion, are linked to early-onset torsion dystonia (DYT-TOR1A), a neurological movement disorder.

TorsinA antibodies are immunodetection tools developed to study the expression, localization, and function of TorsinA in cellular and disease models. These antibodies are crucial for investigating TorsinA’s interaction with cofactors like LAP1 or LULL1. its role in ER stress response, and its involvement in nuclear envelope dynamics. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to analyze tissue distribution (e.g., neuronal tissues) or validate knockout/knockdown models.

Both monoclonal and polyclonal TorsinA antibodies exist, with specificity validated against recombinant proteins or *Tor1a*-deficient samples. Challenges include cross-reactivity with homologous proteins (e.g., TorsinB) and distinguishing between wild-type and mutant forms. Their applications extend to studying dystonia pathophysiology, neurodegeneration, and TorsinA’s potential roles in viral replication or aging. Selecting appropriate antibodies requires careful consideration of epitope regions, host species, and validation data to ensure experimental accuracy.